Harris adopts Biden policies on immigration and Gaza
Ms Harris once held more progressive immigration views as a senator and in her campaign for president in 2020. She had previously advocated for the closure of immigration detention centres and the decriminalisation of illegal crossings.
But on the subject of "securing our border" Ms Harris said "my values have not changed" and referenced her time "prosecuting transnational, criminal organisations" as California attorney general.
Earlier this year, the vice-president supported a hardline bipartisan border security deal that would have included hundreds of millions of dollars for border wall construction.
Trump pressured Republicans in Congress to kill the deal, but Ms Harris has promised to "sign it into law" if elected. She committed to passing it again during the CNN interview.
To explain her moderated immigration view, the Democratic nominee told CNN that her travels across the country as vice-president had made her "believe it is important to build consensus, and it is important to find a common place of understanding of where we can actually solve problems".
Along those lines, Ms Harris committed to include someone "who was a Republican" in her presidential cabinet. She said it would fulfill her promise to be a president “for all Americans”.
"I have spent my career inviting diversity of opinion. I think it’s important to have people at the table when some of the most important decisions are being made that have different views."
Ms Harris also was asked about the war in Gaza, and re-iterated the White House's position that both Israel and Hamas must "get a deal done" and that the Palestinians deserve to have their own country neighbouring Israel.
"This war must end, and we must get a deal that is about getting the hostages out," she said.
She would not commit to an arms embargo on Israel, as some on her party's left flank have demanded.
Mr Walz, who served for decades in the US National Guard, was asked to clarify a comment he in made in which he said he "carried" an assault rifle in "war".
The campaign has clarified that Mr Walz was never in a war zone.
In the interview, the governor said he wore "his emotions on his sleeve" and was "speaking passionately" about the subject of gun crime in schools when he made the inaccurate statement.
That "passion" also extended to his incorrect assertion that his wife had received in-vitro fertilisation (IVF) treatments - which have become a political lightning rod in the US debate over abortion access - to conceive their children.
She received intrauterine insemination, not IVF, though doctors have said that the two fertilisation treatments are often referred to interchangeably.
Mr Walz said his record speaks for itself. He said he did not believe that Americans were "cutting hairs" between the two.
The Minnesota governor was also asked about his son, Gus, who went viral when he proudly proclaimed "That's my dad" at the Democratic National Convention.
"It was just such a visceral, emotional moment that I'm grateful I got to experience it - and I'm so proud of him."
Harris details Biden's decision to drop out of race
Ms Harris described the moment that President Biden called her to share that he had decided to end his re-election bid in July.
She said her family was visiting her when she received the phone call. They had just eaten pancakes and bacon and were working on a puzzle.
"My first thought was not about me, to be honest with you, my first thought was about him," Ms Harris said when asked whether she asked for his endorsement.
The vice-president also maintained that the president could have served again.
"He is so smart, and I have spent hours upon hours with him being in the Oval Office and in the situation room. He has the intelligence, the commitment and judgment and disposition that I think the American people rightly deserve in their president."
She said Trump, by contrast, had none of those qualities.
The wait for Harris's first interview as the nominee
Ms Harris has faced criticism from Republicans and some pundits for refusing to hold a press conference or an on-the-record, in-depth interview until now. Her critics argued that she was avoiding having her record challenged.
Her appearance on CNN marks her first substantive interview since Mr Biden exited race.
Ms Bash, the CNN journalist who conducted the interview of Ms Harris and Mr Walz, was one of the moderators of the 27 June debate between Mr Biden and Trump.
Mr Biden's disastrous performance in that debate was widely seen as what sparked the effort for the president to withdraw from the race.
Ms Harris described the moment that President Biden called her to share that he had decided to end his re-election bid in July.
She said her family was visiting her when she received the phone call. They had just eaten pancakes and bacon and were working on a puzzle.
"My first thought was not about me, to be honest with you, my first thought was about him," Ms Harris said when asked whether she asked for his endorsement.
The vice-president also maintained that the president could have served again.
"He is so smart, and I have spent hours upon hours with him being in the Oval Office and in the situation room. He has the intelligence, the commitment and judgment and disposition that I think the American people rightly deserve in their president."
She said Trump, by contrast, had none of those qualities.
The wait for Harris's first interview as the nominee
Ms Harris has faced criticism from Republicans and some pundits for refusing to hold a press conference or an on-the-record, in-depth interview until now. Her critics argued that she was avoiding having her record challenged.
Her appearance on CNN marks her first substantive interview since Mr Biden exited race.
Ms Bash, the CNN journalist who conducted the interview of Ms Harris and Mr Walz, was one of the moderators of the 27 June debate between Mr Biden and Trump.
Mr Biden's disastrous performance in that debate was widely seen as what sparked the effort for the president to withdraw from the race.